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Chemical & Physical Properties
| Property | Specification |
|---|---|
| Chemical Name | (S)-(+)-Methamphetamine hydrochloride |
| CAS Number | 51-64-9 |
| Purity | 99.5%+ (HPLC/GC-MS/NMR) |
| Enantiomeric Excess | ≥99.8% d-isomer |
| Appearance | Large colorless crystals (1–5 mm) |
| Solubility | >100 mg/mL in water; 50 mg/mL in ethanol; 20 mg/mL in DMSO |
| Melting Point | 170–175°C |
| Molecular Weight | 185.69 g/mol |
| pKa | 9.87 (conjugate acid) |
| LogP | 2.07 |
| Density | 1.1 g/cm³ |
| Refractive Index | 1.52 (20°C) |
Download COA → NC-METH-2025-11A Lab Report
Reagent Test Guide
| Reagent | Expected Reaction | Adulterant Alert |
|---|---|---|
| Marquis | Orange → Green → Blue-Black | Yellow/Brown = Amphetamine |
| Mecke | Green → Blue → Black | No change = PMMA |
| Mandelin | Orange → Green | Red = Opiates |
| Liebermann | Red → Black | Purple = MDMA |
| Simons | No reaction (secondary amine absent) | Blue = MDMA/MDA |
| Froehde | Orange → Green | Brown = Levomethamphetamine |
Every order includes complimentary 6-reagent kit (Marquis, Mecke, Mandelin, Liebermann, Simons, Froehde) and fentanyl test strips.
Research Handling Protocol
- Reconstitution:
- Dissolve 1–10 mg/mL in 0.9% sterile saline (pH 4.5–5.5) under sterile laminar flow
- Filter through 0.22 μm PES membrane for in vivo use
- Dosing Examples:
- Rodent Hyperlocomotion: 0.5–2 mg/kg IP
- Self-Administration: 0.03–0.1 mg/kg/infusion IV
- In Vitro DAT Binding: 10 nM–1 μM
- Storage & Stability:
- Short-term: 2–8°C, desiccated, amber vial
- Long-term: -20°C, vacuum-sealed, stable >36 months
- Solution: Stable 48h at 4°C; freeze aliquots at -80°C
- Safety & Disposal:
- Class A fume hood, double nitrile gloves, full-face shield
- Neutralize spills with 5% sodium bicarbonate
- Dispose via licensed chemical waste (DEA Schedule II)
Our “Precision Protocol” PDF—included free—covers solubility charts, stability data, HPLC calibration curves, and DEA-compliant disposal guidelines.
Pharmacokinetic & Pharmacodynamic Profile
| Parameter | Value |
|---|---|
| Onset (IV/IP) | 5–15 min |
| Peak Plasma | 30–90 min |
| Half-Life | 9–12 hours (CYP2D6 dependent) |
| Volume of Distribution | 3–5 L/kg |
| Protein Binding | ~15–20% |
| Metabolism | Hepatic (CYP2D6 → amphetamine, 4-OH-meth) |
| Excretion | Renal (30–50% unchanged, pH-dependent) |
| DAT IC₅₀ | 0.1–0.3 μM |
| SERT IC₅₀ | 10–20 μM |
| NET IC₅₀ | 0.05–0.1 μM |
Impurity Profile (Batch NC-METH-2025-11A)
| Potential Impurity | Detected Level | Limit |
|---|---|---|
| N-Isopropylbenzylamine | <0.01% | <0.1% |
| Methylsulfonylmethane | ND | <0.05% |
| Ephedrine/Pseudoephedrine | ND | <0.05% |
| Caffeine | ND | <0.1% |
| Fentanyl Analogs | ND | <1 ppm |
| Amphetamine | <0.02% | <0.1% |
| 4-Hydroxymethamphetamine | <0.03% | <0.1% |
ND = Not Detected (LOD: 0.001%)
Stability & Shelf Life
| Condition | Stability Duration | Degradation Rate |
|---|---|---|
| -20°C, desiccated | >36 months | <0.1%/year |
| 2–8°C, light-protected | >24 months | <0.3%/year |
| 25°C, ambient | >12 months | <1%/year |
| Solution (saline, pH 5) | >48 hours at 4°C | <2% loss |
| Solution (DMSO) | >30 days at -20°C | <1% loss |
NMR & Mass Spec Data (Batch NC-METH-2025-11A)
| Analysis | Key Signals |
|---|---|
| ¹H NMR (400 MHz, D₂O) | δ 7.25–7.35 (m, 5H), 3.25 (q, 1H), 2.70 (s, 3H), 1.25 (d, 3H) |
| ¹³C NMR | δ 135.5, 129.8, 128.7, 127.2, 56.3, 33.8, 16.2 |
| MS (ESI+) | m/z 150.1 [M+H]⁺, 91.1 (benzyl), 119.1 (loss of CH₃NH₂) |
Our Services
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- Authenticity Guarantee – Full refund if COA fails
- Technical Consultation – Free protocol design from PhD chemists
- Custom Synthesis – Deuterated (d₃-methyl), ¹⁴C-labeled, or stereoisomers
- Analytical Services – Third-party NMR/MS validation
- Resolution Policy – Solved in <12 hours
Limited Batch – 487 Grams Remaining
Batch NC-METH-2025-11A live now. Next synthesis: Dec 05, 2025.
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