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Meanwhile; Esketamine comes as a solution (liquid) to spray into the nose. For the management of treatment-resistant depression. It is usually sprayed into the nose twice a week during weeks 1–4. Once weekly during weeks 5–8, and then once a week or once every 2 weeks during week 9 and beyond. For the treatment of depressive symptoms in adults with major depressive disorder and suicidal thoughts or actions.

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Furthermore,; if you are using a nasal corticosteroid such as ciclesonide (Alvesco, Omnaris, Zetonna) and mometasone (Asmanex) or nasal decongestant such as oxymetazoline (Afrin) and phenylephrine (Neosynephrine), use it at least 1 hour before using esketamine nasal spray. tell your doctor if you have a blood vessel disease in the brain, chest, stomach area, arms or legs; have arteriovenous malformation (an abnormal connection between your veins and arteries); or have a history of bleeding in your brain. Your doctor will probably tell you not to use esketamine nasal spray.

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